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The crab-eating macaque provides a closer approximation of humans than does the cat for studies of autonomic control, and has a broad array of noninvasive techniques for studying metabolism, neural function, and hemodynamics. The cat model will be used primarily for studies of substrate utilization by the heart. Both models are ideal for the study of the effects of hormones on substrate utilization by the heart. We will investigate the substrate utilization patterns and the hormonal responses to diet changes in conscious animals using an indwelling catheter inserted chronically into the carotid artery, and we will correlate these results with the energy demands imposed by the different feeding states. We have perfected techniques for non-invasively monitoring intracellular pH and lactate concentration in the human heart using dynamic 31-P MRS, and we plan to apply this technique to the study of substrate utilization in the normal and failing human heart. 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